GastroPlus® X Workshop Tokyo 2025 Agenda
GastroPlus® X Introductory Workshop
− January 27th - 29th, 2025
Day 1:
- Introduction
- Solubility/Dissolution
- Precipitation
- Permeability/Absorption
- PBPK Modeling Part 1
Day 2:
- PBPK Modeling Part 2
- Nonlinear Metabolism/Carrier-Mediated Transport
- Compartmental PK
- DDI Predictions
- PK/PD Modeling
Day 3 AM:
- Mechanistic IVIVCs
- Virtual BE
- Q&A (only if time)
Day 3 PM:
Legacy GastroPlus® Workshop
Non-oral deliver and large molecule PBPK Modeling
- Intro to Legacy GastroPlus
- Biologics and LAIs
- General ADR info
- Q&A with any remaining time
GastroPlus® X Advanced DMPK & Clinical Pharmacology Workshop
− January 30th - 31th, 2025
Day 1:
- Intro to PBPK: First-in-human predictions - hepatic & renal clearance
- Transporter-based IVIVE
- Enterohepatic circulation/metabolite tracking modeling
Day 2:
- Special Populations
- Pediatric population predictions
- Pregnancy modeling
- Disease state modeling
- DDI predictions (dynamic/steady state), with focus on auto-induction
- PBPK/PD modeling
- Q&A
GastroPlus® X Advanced Pharmaceutical Development Workshop
− January 30th - 31th, 2025
Day 1:
- Common ion effect on solubility/dissolution
- Precipitation Concepts and Points of Attention
- Proper use of in vitro dissolution data, especially as it relates to the Z-factor model
- Optimizing formulation (release rate) to hit a therapeutic concentration window
Day 2:
- Positive/negative food effect, with focus on issues related to stomach emptying
- Mechanistic deconvolutions and integration with DDDPlus™
- Virtual bioequivalence trials
- Q&A
